Limitation of enzymatic models for predicting myocardial infarct size.
نویسندگان
چکیده
منابع مشابه
Limitation of enzymatic models for predicting myocardial infarct size.
The possibility of predicting myocardial infarct size from early enzyme measurements was studied using a physiological two compartment distribution model. Based on this the time dependent appearance function in plasma was calculated for creatine kinase, aspartate aminotransferase, and lactate dehydrogenase in 29 patients suffering from acute myocardial infarction. On average, the appearance fun...
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T he causal relationship between the rise in activity of certain enzymes in the serum and the occurrence of damage to the myocardium has been established without question. Experiments and histochemical investigations have shown that infarcted heart muscle is rapidly depleted of various enzymes, and that these enzymes appear in an active form in the blood that drains from the infarcted myocardiu...
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Enzymatic estimates of myocardial infarct size based on plasma levels of MB creatine kinase (MB-CK) were compared with anatomic infarct size in 49 human hearts obtained at autopsy. The patients studied had been enrolled in the Multicenter Investigation of Limitation of Infarct Size (MILIS) study program within 18 hr of the onset of acute infarction and were treated at one of five participating ...
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Patients with their first myocardial infarction not initially complicated by severe atrioventricular block or power failure were given a skin test and then randomized to receive either hyaluronidase or placebo in double-blind fashion. Hyaluronidase, 500 IU/kg i.v., was given every 6 hours for 42 hours. Of the 48 eligible patients, 26 received hyaluronidase and 22 received placebo. The mean CK s...
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The February 1990 issue of Circulation contained an editorial comment by Dr. R. Roberts1 concerning our study on enzyme recovery from dog heart.2 We appreciate Roberts' interest in our study, and we agree with him that there is urgent need for methods allowing quantitative estimation of myocardial injury. We feel, however, that some of Roberts' remarks could cause confusion regarding the implic...
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ژورنال
عنوان ژورنال: Heart
سال: 1983
ISSN: 1355-6037
DOI: 10.1136/hrt.50.1.70